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Seth Ari Sim-Son Hoffman

Fellow in Graduate Medical Education
Infectious Diseases Fellow in the Division of Infectious Diseases & Geographic Medicine. Research to benefit under-served populations.

Dr. Seth Ari Sim-Son Hoffman is a clinical postdoctoral fellow in the Stephen P. Luby Lab within the Division of Infectious Diseases & Geographic Medicine, Stanford School of Medicine, Stanford University. His research interests include using advanced immunological, molecular, and analytical tools to design, evaluate, and implement interventions to reduce the burden of infectious diseases in resource-constrained settings. His work seeks to improve global health through the performance of clinical, translational, and implementation research to benefit under-served populations globally. His background includes nearly 20 years of research efforts in molecular biology, computational biology, genomics, global health, and clinical research.

Dr. Hoffman is involved in a broad portfolio of impact-driven research to benefit under-served populations, including research on emerging infectious diseases and pandemic prevention. He is a co-investigator of a randomized controlled trial of FarUV 222nm UVGI and filtered box-fans on reducing viral upper respiratory infection transmission and improving indoor air quality in primary school classrooms in Dhaka, Bangladesh; he is the PI of a typhoid urban water supply surveillance project in Liberia; he is a co-investigator on a project attempting to characterize, using shotgun metagenomic sequencing of placentae and environmental heavy metal sampling, why women in Bangladesh suffer from a disproportionately high rate of stillbirth; he is a co-investigator on a study evaluating the willingness to receive a Phase II Nipah virus vaccine and the appropriate language for communication about a Nipah virus vaccine in Bangladesh; and he led the data analysis and publication of a typhoid conjugate vaccine (Typbar-TCV®, Bharat Biotech) rollout in Navi Mumbai, India targeting 9-month to 16-year-old children. He has conducted clinical research to monitor neutralization resistance mutations in an HIV patient with prolonged SARS-CoV-2 infection and authored a review on emerging and reemerging pediatric viral diseases.


MS, Stanford University, Epidemiology and Clinical Research (2023)
Residency, Internal Medicine, University of Maryland Medical Center (2020)
MD, The Medical School for International Health (MSIH), Ben-Gurion University of the Negev Faculty of Health Sciences in affiliation with Columbia University’s Vagelos College of Physicians and Surgeons (2017)
BA, Cornell University, Anthropology (2012)