Main content start
Seth Ari Sim-Son Hoffman
Instructor, Medicine - Infectious Diseases
Instructor in the Division of Infectious Diseases & Geographic Medicine. Research to benefit under-served populations.
Dr. Seth Ari Sim-Son Hoffman is an Instructor in the Division of Infectious Diseases & Geographic Medicine, Stanford School of Medicine, Stanford University and a member of the Stephen P. Luby Laboratory. His research interests include using advanced immunological, molecular, and analytical tools to design, evaluate, and implement interventions to reduce the burden of infectious diseases in resource-constrained settings. He is particularly interested in developing tools to characterize the epidemiology of mild/subclinical transmission of pathogens, especially those that spread antimicrobial resistance or have pandemic risk, and investigating interventions to interrupt transmission. His work seeks to improve global health through the performance of clinical, translational, and implementation research to benefit under-served populations globally. His background includes nearly 20 years of research efforts in molecular biology, computational biology, genomics, global health, and clinical research.
He is the PI of a US NIH K23 award (1K23AI182452-01: "Modeling the Impact of Interventions to Reduce Typhoidal Salmonella Transmission in the Indo-Pacific"), which is an add-on research effort to the Wellcome Trust-funded Revitalising Informal Settlements and their Environments (RISE) program. He is a co-investigator on a Thrasher Research Fund E.W. "Al" Thrasher" Award entitled "Quantifying the True Burden of Pediatric Typhoidal Salmonella in Dhaka, Bangladesh," studying the subclinical/mild fraction of typhoidal Salmonella incidence in Dhaka, Bangladesh. He is a co-investigator of a randomized controlled trial of FarUVC 222nm UVGI, upper-room 254nm UVGI, and HEPA-filters on reducing viral upper respiratory infection transmission and improving indoor air quality in primary school classrooms in Dhaka, Bangladesh. He is a co-investigator on a project attempting to characterize, using shotgun metagenomic sequencing of placentae and environmental heavy metal sampling, why women in Bangladesh suffer from a disproportionately high rate of stillbirth. He led the data analysis and publication of a typhoid conjugate vaccine (Typbar-TCV®, Bharat Biotech) rollout in Navi Mumbai, India targeting 9-month to 16-year-old children. He has conducted clinical research to monitor neutralization resistance mutations in an HIV patient with prolonged SARS-CoV-2 infection and authored a review on emerging and reemerging pediatric viral diseases.
Dr. Seth Ari Sim-Son Hoffman is an Instructor in the Division of Infectious Diseases & Geographic Medicine, Stanford School of Medicine, Stanford University and a member of the Stephen P. Luby Laboratory. His research interests include using advanced immunological, molecular, and analytical tools to design, evaluate, and implement interventions to reduce the burden of infectious diseases in resource-constrained settings. He is particularly interested in developing tools to characterize the epidemiology of mild/subclinical transmission of pathogens, especially those that spread antimicrobial resistance or have pandemic risk, and investigating interventions to interrupt transmission. His work seeks to improve global health through the performance of clinical, translational, and implementation research to benefit under-served populations globally. His background includes nearly 20 years of research efforts in molecular biology, computational biology, genomics, global health, and clinical research.
He is the PI of a US NIH K23 award (1K23AI182452-01: "Modeling the Impact of Interventions to Reduce Typhoidal Salmonella Transmission in the Indo-Pacific"), which is an add-on research effort to the Wellcome Trust-funded Revitalising Informal Settlements and their Environments (RISE) program. He is a co-investigator on a Thrasher Research Fund E.W. "Al" Thrasher" Award entitled "Quantifying the True Burden of Pediatric Typhoidal Salmonella in Dhaka, Bangladesh," studying the subclinical/mild fraction of typhoidal Salmonella incidence in Dhaka, Bangladesh. He is a co-investigator of a randomized controlled trial of FarUVC 222nm UVGI, upper-room 254nm UVGI, and HEPA-filters on reducing viral upper respiratory infection transmission and improving indoor air quality in primary school classrooms in Dhaka, Bangladesh. He is a co-investigator on a project attempting to characterize, using shotgun metagenomic sequencing of placentae and environmental heavy metal sampling, why women in Bangladesh suffer from a disproportionately high rate of stillbirth. He led the data analysis and publication of a typhoid conjugate vaccine (Typbar-TCV®, Bharat Biotech) rollout in Navi Mumbai, India targeting 9-month to 16-year-old children. He has conducted clinical research to monitor neutralization resistance mutations in an HIV patient with prolonged SARS-CoV-2 infection and authored a review on emerging and reemerging pediatric viral diseases.
Education
Board Certification: American Board of Internal Medicine, Infectious Disease (2022)
Fellowship: Stanford University Infectious Disease Fellowships (2022) CA
Board Certification: American Board of Internal Medicine, Internal Medicine (2020)
Residency: University of Maryland Medical Center (2020) MD
Medical Education: Ben-Gurion University of the Negev (2017) Israel
Fellowship, Infectious Diseases, Stanford University School of Medicine (2024)
MS, Stanford University, Epidemiology and Clinical Research (2023)
Residency, Internal Medicine, University of Maryland Medical Center (2020)
MD, The Medical School for International Health (MSIH), Ben-Gurion University of the Negev Faculty of Health Sciences in collaboration with Columbia University Irving Medical Center (2017)
BA, Cornell University, Anthropology (2012)
Contact
Mail Code
5151