Many regions around the world urgently need new approaches to treating and managing water, wastewater and related solid waste. Most current water infrastructure is at the end of its design life, and not up to challenges posed by drought, population growth, climate change and dwindling government funding. The William and Cloy Codiga Resource Recovery Center (CR2C) at Stanford eases the path to commercialization for promising technologies by providing a unique proving ground. A first-of-its-kind pilot-scale testing facility, it uses a novel core infrastructure and test beds for flexible analysis of mobile treatment systems fed multiple grades of water. CR2C opens the door to market-based solutions that boost water availability, energy independence and environmental resilience.