Krish Seetah's research into environmental issues is two-fold. As a zooarchaeologist he is particularly interested in human-animal relationships and how these can be used as a proxy for understanding human interactions with the environment. Seetah has employed geometric morphometrics as a mechanism for identifying and distinguishing animal populations, and how these are tied to either niche adaptation or agency. His work has centered on horses and cave bears.

Seetah also directs a field project that looks implicitly at human impact on pristine ecosystems. This work has focused on key sites on Mauritius, an island with no settled population prior to the 16th century, and is based on a systematic programme of excavation and environmental sampling. The underlying aims are to better understand the environmental consequences of intense, monoculture, agriculture; the impacts of three distinct European Imperial interventions, and the ecological, dietary, health and social implications of a legacy of slavery, indenture and colonialism.