Chase's research primarily focuses on quantifying the populations, community assemblages, and species interactions of organisms in human-dominated landscapes under the framework of countryside biogeography. Much of his work centers on predictive models, habitat use, and metapopulation and metacommunity dynamics of birds and bats in Coto Brus, Costa Rica. This work is largely informed by the need to crystallize a firm link between diversity of life on the planet, conservation biology, ecosystem services, and natural capital. Specifically, Chase is interested in fine-scale tradeoffs between the conservation of biodiversity and agricultural production in the tropics.